ChemInform Abstract: Enantioselective Synthesis of (-)-Indolizidine 239AB ((3R,5S,8aR)-3- Butyl-5-(3-hydroxypropyl)-octahydroindolizine).

✍ Scribed by VO THANH GIANG VO THANH GIANG; J.-P. CELERIER; G. LHOMMET

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 34 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199704222

✦ Synopsis

Enantioselective Synthesis of (-)-Indolizidine 239AB ((3R,5S,8aR)-3-Butyl-5-(3-hydroxypropyl)-octahydroindolizine).

-A general synthesis for the title compound (XI) is presented as part of studies on the reactivity of chiral cyclic β-enamino esters, e. g. (II). (XI) belongs to a class of alkaloids isolated from poison-frogs of the Dendrobatidae family, which exhibit neuromuscular activity (some yields not given). -(VO THANH GIANG;