The sequential Michael reaction of (S)-4,5-di-O-isopropylidenepent-2enoate la and lb with lithium enolate 2 afforded diastereo-and enantioselec--tively bicyclo[2.2.2]octane 2 and 6 (or 51, respectively. The adducts were efficiently converted into both enantiomeric keto aldehydes c-j-7 and (+)-I. Bic
โฆ LIBER โฆ
Enantioselective Synthesis of Bridgehead Hydroxyl Bicyclo[2.2.2]octane Derivatives via Asymmetric Allylindation.
โ Scribed by Viveca Thornqvist; Sophie Manner; Torbjoern Frejd
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 21 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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