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Enantioselective Synthesis of A Key A-Ring Intermediate for the Preparation of 1α,25-Dihydroxyvitamin D 3

✍ Scribed by Chen, Yan; Ju, Tong


Book ID
127001829
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
414 KB
Volume
13
Category
Article
ISSN
1523-7060

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An efficient enantioselective synthesis
✍ Masakazu Koiwa; Georges P.J Hareau; Fumie Sato 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 99 KB

The asymmetric synthesis of the A-ring of 1α,25-dihydroxyvitamin D 3 , (Z)-2, from 5-tert-butyldimethylsiloxy-2-cyclohexenone [(S)-1], is described where an intramolecular lactonization using cat. scandium triflate is the key reaction.