𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Enantioselective synthesis of a chiral pyridazinone derivative by lipase-catalyzed hydrolysis

✍ Scribed by Noriyuki Yoshida; Masahiro Aono; Takeshi Tsubuki; Katsuya Awano; Tomoshige Kobayashi

Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
143 KB
Volume
14
Category
Article
ISSN
0957-4166

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Preparation of optically pure chiral ami
Preparation of optically pure chiral amines by lipase-catalyzed enantioselective hydrolysis ofN-acyl-amines
✍ Hauke Smidt; Andreas Fischer; Peter Fischer; Rolf D. Schmid πŸ“‚ Article πŸ“… 1996 πŸ› Springer-Verlag 🌐 English βš– 275 KB

A new and effective method using lipase from Candida antarctica (native or Novozym SP-435) for the preparation of enantiopure primary R-amines is reported. Hydrolysis of rat-N-acetyl-amines resulted in high conversion > 40% (168 hrs) and > 48 % (> 240 hrs) and enantiomeric excesses (> 99 %ee) for bo