Enantiocontrolled Construction of Functionalized Tetrahydrofurans: Total Synthesis of (6S,7S,9R,10R)-6,9-Epoxynonadec-18-ene-7,10diol, a Marine Natural Product. -A new strategy for the construction of highly functionalized tetrahydrofurans via the key bis-C 3 building block (III) is developed and ap
Enantioselective synthesis of (6S,7S,9R,10R)-6,9-epoxynonadec-18-ene-7,10-diol, a marine natural product
β Scribed by Susumi Hatakeyama; Kuniya Sakurai; Keiichi Saijo; Seiichi Takano
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 213 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4039
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The stereocontrolled synthesis of (6S,7S,9R, 10R)-6,9-epoxynonadec-18-ene-7,10-diol, isolated from the brown alga, Notheia anomala, has been achieved. The key 2,3,5-trisubstituted tetrahydrofuran ring was constructed by alkylation of the sulfonyl-stabilized oxiranly anion followed by 5-endo cyclizat
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