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Enantioselective synthesis of 4-aminocyclopent-2-ene-1-one from tricyclo[5.2.1.02,6]decenyl enaminones

✍ Scribed by Namakkal G. Ramesh; Antonius J.H. Klunder; Binne Zwanenburg

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
338 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

An efficient enantioselective synthesis of 4-amino-cyclopent-2-ene-l-one 12 from enaminones 8 and and its diastereomer has been accomplished vin a one step 'electron transfer reduction of the enaminone double bond and concomitant removal of an a-methylbenzyl group, followed by a [4 + 21 cycloreversion strategy.

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