Enantioselective Synthesis of 3,4-Disubstituted cis - and trans -1,2,5-Thiadiazolidine-1,1-dioxides as Precursors for Chiral 1,2-Diamines
✍ Scribed by Schüttler, Christian; Li-Böhmer, Zhen; Harms, Klaus; von Zezschwitz, Paultheo
- Book ID
- 121252054
- Publisher
- American Chemical Society
- Year
- 2013
- Tongue
- English
- Weight
- 228 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1523-7060
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract An improved synthesis for the preparation of 3‐oxo‐1,2,5‐thiadiazolidine 1,1‐dioxides has been developed. This facile two‐step procedure fromα‐amino acid esters and chlorosulfonyl isocyanate results in excellent yields of products.
A sulfahydantoin (3-oxo-1,2,5-thiadiazolidine 1,1-dioxides) absolute configuration of the chiral centers for the derivative L-Phe-D-Ala, a congener of the series, was established by X-motif is used as a new type of peptidic constraint to lock two consecutive amide nitrogens by a sulfonyl bridge. The