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Enantioselective synthesis of (2S)-2-(4-phosphonophenylmethyl)-3-aminopropanoic acid suitably protected for peptide synthesis

✍ Scribed by Wang-Qing Liu; Catherine Olszowy; Laurent Bischoff; Christiane Garbay

Book ID: 104250431
Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 92 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00004-7

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✦ Synopsis

Protected D-b-2-(4-phosphono) phenylalanine was prepared by a multistep synthesis, involving the diastereoselective alkylation of a chiral enolate. This new compound can be further incorporated into peptidic backbone by means of solid-phase peptide synthesis in order to synthesize short peptides adopting b-turn or a-helix conformations.

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