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Enantioselective Synthesis of 2-Methyl-2-hydroxy-.gamma.-butyrolactone and Its Application in the Asymmetric Synthesis of Frontalin and Mevalonolactone

✍ Scribed by Davis, Franklin A.; Reddy, G. Venkat; Chen, Bang-Chi; Kumar, Anil; Haque, M. Serajul


Book ID
121399032
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
720 KB
Volume
60
Category
Article
ISSN
0022-3263

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Preparation ofα-methyl-γ-butyrolactone:
✍ Vladislav Semak; Andrej Boháč; Marta Sališová; Gabriela Addová; Peter Danko 📂 Article 📅 2008 🏛 Versita 🌐 English ⚖ 190 KB

## Abstract α-Methyl-γ-butyrolactone (III) has been prepared directly from γ-butyrolactone (I) in 89 % yield by selective monomethylation conditions: K2CO3/DMC/210°C/7 h. The reaction mechanism was elucidated and described. An intermediate and two byproducts: methyl tetrahydro-3-methyl-2-oxofuran-3