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ChemInform Abstract: Enantioselective Synthesis of 2-Methyl-2-hydroxy-γ-butyrolactone and Its Application in the Asymmetric Synthesis of Frontalin and Mevalonolactone.

✍ Scribed by F. A. DAVIS; G. V. REDDY; B.-C. CHEN; A. KUMAR; M. S. HAQUE


Book ID
112027202
Publisher
John Wiley and Sons
Year
2010
Weight
38 KB
Volume
27
Category
Article
ISSN
0931-7597

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Preparation ofα-methyl-γ-butyrolactone:
✍ Vladislav Semak; Andrej Boháč; Marta Sališová; Gabriela Addová; Peter Danko 📂 Article 📅 2008 🏛 Versita 🌐 English ⚖ 190 KB

## Abstract α-Methyl-γ-butyrolactone (III) has been prepared directly from γ-butyrolactone (I) in 89 % yield by selective monomethylation conditions: K2CO3/DMC/210°C/7 h. The reaction mechanism was elucidated and described. An intermediate and two byproducts: methyl tetrahydro-3-methyl-2-oxofuran-3