Enantioselective Reduction of Ketones and Imines Catalyzed by (CN-Box)ReV–Oxo Complexes

✍ Scribed by Kristine A. Nolin; Richard W. Ahn; Yusuke Kobayashi; Joshua J. Kennedy-Smith; F. Dean Toste

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 324 KB
• Volume: 16
• Category: Article
• ISSN: 0947-6539
• DOI: 10.1002/chem.201001164

✦ Synopsis

Abstract

The development and application of chiral, non‐racemic Re^V^–oxo complexes to the enantioselective reduction of prochiral ketones is described. In addition to the enantioselective reduction of prochiral ketones, we report the application of these complexes to 1) a tandem Meyer–Schuster rearrangement/reduction to access enantioenriched allylic alcohols and 2) the enantioselective reduction of imines.