Enantioselective Polyol Synthesis via the Cope Rearrangement of Chiral Aldol Products. A Synthesis of the C1-C10-Fragment of Nystatin A1
โ Scribed by Christoph Schneider; Markus Rehfeuter
- Book ID
- 108386381
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 587 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
Compound 8 representing fhe Ct-CtO fragment of nystafin At has been synthesized from nystafin Af by degradation and by total synthesis. Comparison of the two samples revealed the 3R, 5R, 7R stereochemistry for the three nystafin A I centers. Nystatin At (I)1 is a clinically used polyene macrolide
The 3R, SR and 7R cOnfigUrQtiOtI.3 for nystatin A hQV@ been aSSigned through a comparison of synthetic and natural fmgment 3. The key step sf {he synthetic sequence is a nucleophilic oxirane opening by an a-glycosyl copper reagent. We recently reported1 the 3R\*, 5R\* and 7R\* relative configuration