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Synthesis of the C1C10 fragment of the macrolide antibiotic Nystatin A1 from a chiral building block obtained via chemoenzymatic approach

✍ Scribed by C. Bonini; A. Giugliano; R. Racioppi; G. Righi


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
200 KB
Volume
37
Category
Article
ISSN
0040-4039

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Synthesis and stereochemical assignment
✍ K.C. Nicolaou; Kyo Han Ahn 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 284 KB

Compound 8 representing fhe Ct-CtO fragment of nystafin At has been synthesized from nystafin Af by degradation and by total synthesis. Comparison of the two samples revealed the 3R, 5R, 7R stereochemistry for the three nystafin A I centers. Nystatin At (I)1 is a clinically used polyene macrolide