Enantioselective Pharmacokinetics of Ibuprofen and Involved Mechanisms
β Scribed by Hao, Haiping; Wang, Guangji; Sun, Jianguo
- Book ID
- 115534103
- Publisher
- Informa plc
- Year
- 2005
- Tongue
- English
- Weight
- 260 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0360-2532
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The pharmacokinetics of ibuprofen diethylcarbonate (ibudice) and naproxen diethythylcarbonate (napdice), two new diethylcarbonate prodrugs of ibuprofen and naproxen, was investigated in dogs. The rationale for the development of ibudice and napdice was that esterification of the carboxylic moiety of