Enantioselective CE method for pharmacokinetic studies on ibuprofen and its chiral metabolites with reference to genetic polymorphism

Enantioselective in-line and off-line CE

Enantioselective in-line and off-line CE methods for the kinetic study on cimetidine and its chiral metabolites with reference to flavin-containing monooxygenase genetic isoforms

✍ Xin Hai; Erwin Adams; Jos Hoogmartens; Ann Van Schepdael 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 183 KB

## Abstract An in‐line screening and an off‐line chiral CE method were developed to determine the stereoselectivity of flavin‐containing monooxygenase (FMO) isoforms using cimetidine (CIM) as a substrate. The S‐oxygenation of CIM was investigated using achiral chemical oxidants and (human supersome