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Enantioselective Organocatalytic Friedel–Crafts Alkylation Reaction of Indoles with 5-Hydroxyfuran-2(5 H )-one: Access to Chiral γ-Lactones and γ-Lactams via a Ugi 4-Center 3-Component Reaction

✍ Scribed by Riguet, Emmanuel

Book ID: 120291473
Publisher: American Chemical Society
Year: 2011
Tongue: English
Weight: 956 KB
Volume: 76
Category: Article
ISSN: 0022-3263
DOI: 10.1021/jo201184p

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ChemInform Abstract: Enantioselective Or

ChemInform Abstract: Enantioselective Organocatalytic Friedel—Crafts Alkylation Reaction of Indoles with 5-Hydroxyfuran-2(5H)-one: Access to Chiral γ-Lactones and γ-Lactams via a Ugi 4-Center 3-Component Reaction.

✍ Emmanuel Riguet 📂 Article 📅 2012 🏛 John Wiley and Sons ⚖ 58 KB 👁 1 views

## Abstract The prolinol‐catalyzed treatment of indoles with the furanone (II) followed by reduction and lactonization provides an efficient approach to chiral lactones of type (III) and (IX).