✦ LIBER ✦
ChemInform Abstract: Enantioselective Organocatalytic Friedel—Crafts Alkylation Reaction of Indoles with 5-Hydroxyfuran-2(5H)-one: Access to Chiral γ-Lactones and γ-Lactams via a Ugi 4-Center 3-Component Reaction.
✍ Scribed by Emmanuel Riguet
- Publisher
- John Wiley and Sons
- Year
- 2012
- Weight
- 58 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
The prolinol‐catalyzed treatment of indoles with the furanone (II) followed by reduction and lactonization provides an efficient approach to chiral lactones of type (III) and (IX).