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Enantioselective nickel-catalyzed conjugate addition of dialkylzinc to chalcones using chiral α-amino amides

✍ Scribed by Jorge Escorihuela; M. Isabel Burguete; Santiago V. Luis

Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
233 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis

A series of a-amino amides derived from natural amino acids (alanine, valine, phenylalanine, isoleucine, and phenylglycine) have been synthesized and fully characterized. Their Ni(II) complexes prepared from Ni(acac) 2 catalyze the enantioselective conjugate addition of diethylzinc to chalcones in high yields and in good enantioselectivities (up to 84%). The side chain of the amino acid and the substituents in the amide nitrogen govern the enantioselectivity of the catalytic process.

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Enantioselective conjugate addition of d
Enantioselective conjugate addition of diethylzinc to chalcone catalyzed by Co(acac)2 and chiral amino alcohols
✍ AndréH.M. de Vries; Ben L. Feringa 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 135 KB

Co(acac) 2 in the presence of chiral ligands has been employed as catalyst for the enantioselective conjugate addition of diethylzinc to chalcone. With chiral amino alcohols derived from (+)-camphor, enantioselectivities up to 83% were achieved.

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