Enantioselective Michael reaction of ketone lithium enolates using a chiral amine ligand
✍ Scribed by Kōsuke Yasuda; Mitsuru Shindo; Kenji Koga
- Book ID
- 103414189
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 210 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
An efficient enantioselective alkylation of the lithium enolates of cyclohexanone and ltetralone with reactive alkyl halides was realized using a stoichiometric amount of a tetradentate chiral amine as a ligand for the lithium in the presence of lithium bromide in toluene.
## Diasterwselective akylation of chital lithium etwlates (dl-, (R)-and (S)-9) derivedjbm 4-t-butykycioh in the presence da chiral secondary amine (R)_I and litkium bromide was studied., It is shown that (R)-1 re t&a&s the direction of tke attack of electrophi~s. stereoselective axial attack ws oL e