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Enantioselective Michael Addition of 2-Nitropropane to Chalcone Analogues Catalyzed by Chiral Azacrown Ethers Based on α-D-Glucose and D-Mannitol.

✍ Scribed by Tibor Bako; Peter Bako; Gyoergy Keglevich; Nikoletta Bathori; Matyas Czugler; Janos Tatai; Tibor Novak; Gyula Parlagh; Laszlo Toeke


Publisher
John Wiley and Sons
Year
2003
Weight
135 KB
Volume
34
Category
Article
ISSN
0931-7597

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Asymmetric Michael addition of 2-nitropr
✍ Péter Bakó; László Töke; Áron Szöllösy; Petra Bombicz 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 173 KB 👁 1 views

Michael addition of 2-nitropropane 4 to a chalcone 3 catalyzed by crown ethers incorporating two glucose units (of 1 type) afforded the adduct 5 with an R-enantiomer excess (28% ee) while the aza-crown ethers containing one glucose unit (of 2 type) gave the same adduct favoring the S-enantiomer unde