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Enantioselective Kinetics of Verapamil and Norverapamil in Isolated Perfused Rat Livers

โœ Scribed by Reza Mehvar; James M. Reynolds; Megan A. Robinson; James A. Longstreth

Book ID
110379762
Publisher
Springer US
Year
1994
Tongue
English
Weight
901 KB
Volume
11
Category
Article
ISSN
0724-8741

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In perfused livers from fed rats, rates of glucose production (glycogenolysis) were 133 f 12 pmollglhr. Infusion of 2 pM verapamil into these livers decreased the rates of glucose production significantly to 97 \* 15 pmollglhr within 10 min. Conversely, rates of production of lactate plus pyruvate (

ENANTIOSELECTIVE DISTRIBUTION OF VERAPAM
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In this in vitro study, the distribution of the enantiomers of verapamil (VER) and its active metabolite, norverapamil (NOR), into the red blood cells (RBCs) of humans and rats was investigated using a chiral liquid chromatographic assay. When plasma was replaced with buffer, the distribution of VER