Enantioselective Iridium-Catalyzed Vinylogous Reformatsky-Aldol Reaction from the Alcohol Oxidation Level: Linear Regioselectivity by Way of Carbon-Bound Enolates

✍ Scribed by Abbas Hassan; Jason R. Zbieg; Prof. Michael J. Krische

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 310 KB
• Volume: 123
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/ange.201100646

✦ Synopsis

Scheme 1. Catalytic enantioselective vinylogous aldol reactions. PG = protecting group.

Scheme 2. Carbonyl addition by way of primary s-ally haptomers typically generates branched products as anti-diastereomers.