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Enantioselective Friedel–Crafts Alkylation of Thiophenes with Ethyl Glyoxylate: Easy Access to Chiral Secondary Alcohols

✍ Scribed by Zhong Huang; Jingchang Zhang; Yuqiang Zhou; Nai-Xing Wang


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
140 KB
Volume
2011
Category
Article
ISSN
1434-193X

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## Abstract The prolinol‐catalyzed treatment of indoles with the furanone (II) followed by reduction and lactonization provides an efficient approach to chiral lactones of type (III) and (IX).