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Enantioselective decarboxylation–reprotonation of an α-amino malonate derivative as a route to optically enriched cyclic α-amino acid

✍ Scribed by Louis M.-A. Rogers; Jacques Rouden; Ludovic Lecomte; Marie-Claire Lasne

Book ID: 104253376
Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 119 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)00557-4

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✦ Synopsis

Chiral tertiary amines have been examined as enantioselective decarboxylation-reprotonation reagents for the synthesis of a-amino acids via a-aminomalonates. N-Acetyl pipecolic acid ethyl ester, as a model compound, was obtained in good yield and 52% enantiomeric excess using a quinidine derived base.

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