Enantioselective Conjugate Addition of Nitro Compounds to α,β-Unsaturated Ketones: An Experimental and Computational Study
✍ Scribed by Dr. Rubén Manzano; Dr. José M. Andrés; Dr. Rosana Álvarez; María D. Muruzábal; Prof. Dr. Ángel R. de Lera; Prof. Dr. Rafael Pedrosa
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 370 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0947-6539
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## Abstract The first example of an organocatalytic asymmetric Michael addition of aldehydes to α,β‐unsaturated thiol esters promoted by chiral diphenylprolinol silyl ether is presented. The reaction occurs with good yields, diastereoselectivity and excellent enantioselectivity.
Organocatalysis [1] has expanded widely within the last few years, since the rediscovery of the proline-catalyzed aldol reaction. [2] Since then, several different methods, such as fluorination, [3] chlorination, [4] bromination, [5] sulfenylation, [6] amination, [7] and Mannich reactions, [8] have