✍ Scribed by Ashok K. Yadav; Meera Manju; Pukh Raj Chhinpa
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This work describes preparative scale enantioselective cathodic reduction of some prochiral ketones, viz. 3,4-dihydro-1(2H)-naphthaleneone, 2-octanone, 1-phenyl-2-propanone, E-3-octen-2-one, 1-octyn-3-one, 1-undecyn-3-one, 1-tetradecyn-3-one at mercury pool in N,N-dimethyl formamide (DMF)-2-propanol (9.5:0.5), using tetrabutylammonium tetrafluoroborate (TBA•BF 4 ), as supporting electrolyte and (-)-N,N%-dimethylquininium tetrafluoroborate (DMQ•2BF 4 ), as a enantioselective inductor. The products obtained were corresponding (S)-alcohols in 24-70% ee.
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An Optimized in situ Procedure for the Oxazaborolidine Catalyzed Enantioselective Reduction of Prochiral Ketones. -The catalyst prepared from (S)-diphenyl prolinol is found to be the best amongst several other analogues for the reduction of alkyl aryl ketones. -(PRASAD, K. R.
The cathodic reductions of two series of substituted quinoxaline di-N-oxides and quinoxalines in acetonitrile were measured in the potential range of 0 to -2.0 V and 0 to -2.3 V us see, respectively. Two irreversible reductions were observed in the first series, and one reversible reduction for the