Enantioselective catalytic ring opening of epoxides with carboxylic acids
β Scribed by Eric N. Jacobsen; Fumitoshi Kakiuchi; Reed G. Konsler; Jay F. Larrow; Makoto Tokunaga
- Book ID
- 104256160
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 196 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
The chiral Co(salen) complex 3 is an effective catalyst for the asymmetric ringopening of meso epoxides with benzoic acid. Enantioselectivities of 55-93% were obtained with a range of substrates.
π SIMILAR VOLUMES
## Abstract **Cooperative metal centers** in a bimetallic catalyst facilitate the highly enantioselective ring opening of __meso__ aziridines **1** with silyl nucleophiles (see scheme; TMS=trimethylsilyl). The 1,2βazidoamides **2** and 1,2βamidonitriles **3** obtained in this way in high yields and
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