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Enantioselective catalytic ring opening of epoxides with carboxylic acids

✍ Scribed by Eric N. Jacobsen; Fumitoshi Kakiuchi; Reed G. Konsler; Jay F. Larrow; Makoto Tokunaga


Book ID
104256160
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
196 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis


The chiral Co(salen) complex 3 is an effective catalyst for the asymmetric ringopening of meso epoxides with benzoic acid. Enantioselectivities of 55-93% were obtained with a range of substrates.


πŸ“œ SIMILAR VOLUMES


Catalytic, Enantioselective Ring Opening
✍ Christoph Schneider πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 347 KB πŸ‘ 2 views

## Abstract **Cooperative metal centers** in a bimetallic catalyst facilitate the highly enantioselective ring opening of __meso__ aziridines **1** with silyl nucleophiles (see scheme; TMS=trimethylsilyl). The 1,2‐azidoamides **2** and 1,2‐amidonitriles **3** obtained in this way in high yields and