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Catalytic Promiscuity of Halohydrin Dehalogenase and its Application in Enantioselective Epoxide Ring Opening

✍ Scribed by Ghannia Hasnaoui-Dijoux; Maja Majerić Elenkov; Jeffrey H. Lutje Spelberg; Bernhard Hauer; Dick B. Janssen

Book ID
101816748
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
171 KB
Volume
9
Category
Article
ISSN
1439-4227

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📜 SIMILAR VOLUMES

Enantioselective Ring Opening of Epoxide
Enantioselective Ring Opening of Epoxides with Cyanide Catalyzed by Halohydrin Dehalogenases: A New Approach to Non-Racemic β-Hydroxy Nitriles.
✍ Maja Majeric Elenkov; Bernhard Hauer; Dick B. Janssen 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 30 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Enantioselective Ring Opening of Epoxide
Enantioselective Ring Opening of Epoxides with Cyanide Catalysed by Halohydrin Dehalogenases: A New Approach to Non-Racemic β-Hydroxy Nitriles
✍ Maja Majerić Elenkov; Bernhard Hauer; Dick B. Janssen 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 99 KB

## Abstract Halohydrin dehalogenases (HheA, HheB and HheC) were found to efficiently catalyse a carbon‐carbon bond forming reaction between terminal aliphatic epoxides and cyanide, yielding β‐hydroxy nitriles. With all three enzymes nucleophilic ring opening of epoxides proceeds with high regiosele