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Enantioselective and Diastereoselective Mukaiyama−Michael Reactions Catalyzed by Bis(oxazoline) Copper(II) Complexes

✍ Scribed by Evans, David A.; Scheidt, Karl A.; Johnston, Jeffrey N.; Willis, Michael C.


Book ID
115486748
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
319 KB
Volume
123
Category
Article
ISSN
0002-7863

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Enantioselective mukaiyama-michael react
✍ Anna Bernardi; Giorgio Colombo; Carlo Scolastico 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 236 KB

The conjugate addition of propionate silylketcne acetal 1 to 2-carbomethoxy cyclopentenone is promoted by bis(oxazoline)-Cu(ll) complexes with high diastcreosclectivity and good enantiomeric excesses. The absolute configuration of the product can bc controlled by varying the copper counterion. A ca