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Enantioselective analysis of tolvaptan in rat and dog sera by high-performance liquid chromatography and application to pharmacokinetic study

✍ Scribed by Furukawa, Masayuki; Yamasaki, Yuko; Hirao, Yukihiro; Umehara, Ken


Book ID
125795091
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
788 KB
Volume
965
Category
Article
ISSN
1873-376X

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## Abstract A simple, specific and sensitive HPLC method with UV detection was developed and validated for the determination of tectoridin in rat plasma for the first time. Chromatographic separation was performed on a Welchrom^TM^ C~18~ column (150 Γ— 4.6Β mm, i.d., 5Β Β΅m) at a flow rate of 1.0Β mLΒ mi