Metabolism of thalidomide in human micro
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Steve K. Teo; P. J. Sabourin; K. O'Brien; K. A. Kook; S. D. Thomas
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Article
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2000
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John Wiley and Sons
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English
โ 117 KB
๐ 1 views
Previous in vitro studies in rat microsomal preparations suggested that thalidomide is metabolized by the cytochrome P450 system (CYP). In this study, we examined the extent of thalidomide metabolism by preparations of pooled human microsomes, microsomes containing cloned human CYP isozymes (CYP1A2,