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Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes

โœ Scribed by Breyer-Pfaff, Ursula; Pfandl, Brigitte; Nill, Karl; Nusser, Elfriede; Monney, Christian; Jonzier-Perey, Michele; Baettig, Dominique; Baumann, Pierre


Book ID
109845127
Publisher
Nature Publishing Group
Year
1992
Tongue
English
Weight
641 KB
Volume
52
Category
Article
ISSN
0009-9236

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Metabolism of thalidomide in human micro
โœ Steve K. Teo; P. J. Sabourin; K. O'Brien; K. A. Kook; S. D. Thomas ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 117 KB ๐Ÿ‘ 1 views

Previous in vitro studies in rat microsomal preparations suggested that thalidomide is metabolized by the cytochrome P450 system (CYP). In this study, we examined the extent of thalidomide metabolism by preparations of pooled human microsomes, microsomes containing cloned human CYP isozymes (CYP1A2,