## Abstract The complex generated in situ from optically active sulfonamide BCS and Ti(OβiPr)~4~ is employed under optimized conditions for the synthesis of enantioenriched propargylic alcohols (up to 65% e.e.).
Enantioselective alkynylation of aldehydes catalyzed by a camphor sulfonylated amino alcohols titanium(IV) catalyst system
β Scribed by Shaohua Gou; Zhongbin Ye; Zhiyu Huang; Xiping Ma
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 142 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0268-2605
- DOI
- 10.1002/aoc.1622
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π SIMILAR VOLUMES
## Abstract The easily prepared and recoverable chiral __N__βsulfonylated __Ξ²__βamino alcohol **2** in combination with Ti(OPrβ__i__)~4~was found to be an effective chiral catalyst for the enantioselective addition of alkynylzinc to ketones, which gave the useful products, __i.e.__ chiral tertiary
## Abstract An __N__βsulfonylated Ξ²βamino alcohol (__R__,__S__,__S__,__R__)β**9** with four stereogenic centers is prepared. The titanium complex of **9** is an effective catalyst to induce excellent enantioselectivities for diethylzinc addition to aromatic aldehydes with ee values up to 99%. The f