Enantioselective addition of diethylzinc to aldehydes using 2-azanorbornylmethanols and 2-azanorbornylmethanethiol as a catalyst

✍ Scribed by Hiroto Nakano; Noriyuki Kumagai; Hisao Matsuzaki; Chizuko Kabuto; Hiroshi Hongo

• Book ID: 104361142
• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 737 KB
• Volume: 8
• Category: Article
• ISSN: 0957-4166
• DOI: 10.1016/s0957-4166(97)00118-3

✦ Synopsis

Optically active 2-azanorbomylmethanols and 2-azanorbomylmethanethiol were prepared from ethyl (1 S,3S,4R)-2-[(R)-1-phenylethyl]-2-azabicyclo[2.2.1 ]hept-5 -ene-3-carboxylate and catalyzed the enantioselective addition of diethylzinc to aldehydes to give optically active secondary alcohols. ~) 1997 Elsevier Science Ltd