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Enantioresolution and absolute configurations of chiral meta-substituted diphenylmethanols as determined by x-ray crystallographic and 1H NMR anisotropy methods

✍ Scribed by Masashi Kosaka; Takeo Sugito; Yusuke Kasai; Shunsuke Kuwahara; Masataka Watanabe; Nobuyuki Harada; Gabriel E. Job; Alex Shvet; William H. Pirkle


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
147 KB
Volume
15
Category
Article
ISSN
0899-0042

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✦ Synopsis


Abstract

meta‐Substituted diphenylmethanols were enantioresolved by the method of chiral phthalic acid yielding enantiopure alcohols. Their absolute configurations were unambiguously determined by X‐ray crystallography of chiral phthalate esters and/or by the ^1^H NMR anisotropy method using 2‐methoxy‐2‐(1‐naphthyl)propionic acid. Chirality 15:324–328, 2003. © 2003 Wiley‐Liss, Inc.


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