Absolute configuration of the thyroid hormone analog KAT-2003 as determined by the 1H NMR anisotropy method with a novel chiral auxiliary, MαNP acid

✍ Scribed by Toshihiro Nishimura; Hiromi Taji; Nobuyuki Harada

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 244 KB
• Volume: 16
• Category: Article
• ISSN: 0899-0042
• DOI: 10.1002/chir.10301

✦ Synopsis

Abstract

The absolute configuration of the chiral thyroid hormone analog KAT‐2003 (+)‐2, showing hypocholesterolemic activities, decreases of hepatic triglyceride contents with lowering cardiac side effects, and significant inhibitory effect for the second primary hepatocellular carcinoma, was determined as S by the ^1^H NMR anisotropy method using a novel chiral auxiliary, 2‐methoxy‐2‐(1‐naphtyl)propionic acid (MαNP acid). Chirality 16:13–21, 2004. © 2003 Wiley‐Liss, Inc.