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Enantiomerically pure synthesis and antiviral evaluation of [(2′S, 3′S)-bis(hydroxymethyl)azetidin-1-yl] purine nucleosides: Analogs of oxetanocin-A

✍ Scribed by Shigeru Nishiyama; Yoshiko Kikuchi; Hiroko Kurata; Shosuke Yamamura; Takao Izawa; Takemitsu Nagahata; Ryuji Ikeda; Kuniki Kato


Book ID
108038895
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
192 KB
Volume
5
Category
Article
ISSN
0960-894X

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Synthesis of enantiomerically pure 9[(1′
✍ Eiko Ichikawa; Shosuke Yamamura; Kuniki Kato 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 194 KB

The enantiomerically pure synthesis of 9-[(l'R,2'R,3'S)-bis(hydroxymethyl)thietan-l'-yl]adenine 2, 3'-thio analog of oxetanocin A, was achieved via coupling with sulfoxide 17 and 6-chloropurine in the presence of TMSOTf and Et3N under the Pummerer reaction conditions.