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ChemInform Abstract: Enantiomerically Pure Synthesis and Antiviral Evaluation of ((2′S,3′S)- Bis(hydroxymethyl)azetidin-1-yl)purine Nucleosides: Analogues of Oxetanocin-A.

✍ Scribed by S. NISHIYAMA; Y. KIKUCHI; H. KURATA; S. YAMAMURA; T. IZAWA; T. NAGAHATA; R. IKEDA; K. KATO


Book ID
112027399
Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
27
Category
Article
ISSN
0931-7597

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Synthesis of enantiomerically pure 9[(1′
✍ Eiko Ichikawa; Shosuke Yamamura; Kuniki Kato 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 194 KB

The enantiomerically pure synthesis of 9-[(l'R,2'R,3'S)-bis(hydroxymethyl)thietan-l'-yl]adenine 2, 3'-thio analog of oxetanocin A, was achieved via coupling with sulfoxide 17 and 6-chloropurine in the presence of TMSOTf and Et3N under the Pummerer reaction conditions.