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Enantiomerically pure 1,2,5-triphenylphospholane through the synthesis and resolution of the chiral trans-(2,5)-diphenylphospholanic acid

✍ Scribed by Frédéric Guillen; Jean-Claude Fiaud

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
190 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis and resolution of trans-(2,5)-diphenylphospholanic acid 7 is described. The phosphinic acid 7 was converted into optically active (1,2,5)-triphenylphospholane 5 which was used as a chiral ligand in Rhcatalyzed hydrogenation of N-acetyl dehydrophenylalanine methyl ester to give quantitative yield of methyl Nacetylphenylalaninate with 82 % e.e.

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