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Enantiomeric resolution of new triazole compounds by high-performance liquid chromatography

✍ Scribed by Chunguang Lv; Guifang Jia; Wentao Zhu; Jing Qiu; Xinquan Wang; Zhiqiang Zhou

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
452 KB
Volume
30
Category
Article
ISSN
1615-9306

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✦ Synopsis

Abstract

Cellulose tris(3,5‐dimethylphenylcarbamate) (CDMPC) was synthesized and coated on aminopropylsilica to prepare a chiral stationary phase (CSP). HPLC methods were developed for the direct enantioseparation of 12 chiral triazole compounds on the CSP. The separations were made using normal phase methodology with a mobile phase consisting of n‐hexane‐alcohol (ethanol, 1‐propanol, 1‐butanol, 2‐propanol, and t‐butanol) in various portions. The column temperatures were studied for the optimization of the resolutions. The effects of structural features of the solutes on the discrimination between the enantiomers were examined. Baseline separation was easily obtained in many cases.

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