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An NMR tool for cyclodextrin selection in enantiomeric resolution by high-performance liquid chromatography

✍ Scribed by Antonio Laverde Jr; Gelson J. A. da Conceição; Sonia C. N. Queiroz; Fred Y. Fujiwara; Anita J. Marsaioli

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
209 KB
Volume
40
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

Complexation‐induced chemical shifts and diffusion coefficients (HR‐DOSY) of enantiomers with native and derivatized cyclodextrins were used for calculations of the apparent binding constants of three cyclohexanone inclusion complexes. Correlations between these data and high‐performance liquid chromatography were established, revealing that this approach can be applied as an alternative method to predict enantiomeric discrimination. Copyright © 2002 John Wiley & Sons, Ltd.

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