𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Enantiomer separation by capillary SFC and GC on immobilized octakis(2,6-di-O-methyl-3-O-pentyl)-γ-cyclodextrin

✍ Scribed by Dönnecke, Jürgen ;König, Wilfried A. ;Gyllenhaal, Olle ;Vessman, Jörgen ;Schulze, Christian

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
495 KB
Volume
17
Category
Article
ISSN
0935-6304

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Heptakis(2,6‐di‐O‐methyl‐3‐O‐pentyl) (2‐O‐methyl‐6‐O‐oct‐1‐enyl‐3‐O‐pentyl)‐γ‐cyclodextrin was immobilized to narrow‐bore fused silica capillaries after selective modification. One tert‐butyldimethylsilyl group was introduced into octakis‐(2‐O‐methyl‐3‐O‐pentyl)‐γ‐cyclodextrin in order to get a pure monofunctionalized cyclodextrin derivative. During synthesis the tert‐butyldimethylsilyl group was replaced by an anchoring group to bind the cyclodextrin to a polysiloxane. After thermal immobilization of the modified polysiloxane this new chiral stationary phase was applied in GC and SFC. High efficiency separations were obtained in GC. In SFC very polar compounds could be chromatographed at low temperatures resulting in higher separation factors as compared to GC.

📜 SIMILAR VOLUMES

Cyclodextrin derivatives for GC separati
Cyclodextrin derivatives for GC separation of racemic mixtures of volatile compounds. Part VIII: 2,6-di-O-methyl-3-O-pentyl-γ-cyclodextrin and 2,6-di-O-methyl-3-O-(4-oxo-pentyl)- and 2,6-di-O-pentyl-3-O-(4-oxo-pentyl)-β-and -γ-cyclodextrins
✍ Bicchi, Carlo ;D'amato, Angela ;Manzin, Valeria ;Galli, Anna ;Galli, Mario 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 309 KB 👁 1 views

In previous papers, 2,6-di-O-methyl-3-O-pentyl-~-cyclodextrin (CD) was demonstrated to be successful in separating volatile compounds, while avoiding the drawbacks of 2,3,6-tri-O-methyl-P-CD in terms of column stability and operating temperature. Since a CD chiral selector of universal use has not y

Synthesis and Silica-Based Immobilizatio
Synthesis and Silica-Based Immobilization of Monofunctionalized Heptakis(2,6-di-O-methyl-3-O-pentyl)-β-cyclodextrin for Enantioselective Capillary-HPLC
✍ Dittmann, Helmutt ;König, Wilfried A. 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 133 KB 👁 2 views

Heptakis(2,6-di-O-methyl-3-O-pentyl)-b-cyclodextrin was monofunctionalized by the regioselective introduction of exactly one x-epoxyoctyl group at the primary site of the cyclodextrin. The site-specifically substituted cyclodextrin was immobilized to commercially available aminopropyl silica by nucl

Cyclodextrin derivatives for the GC sepa
Cyclodextrin derivatives for the GC separation of racemic mixtures of volatile compounds. Part VI: The influence of the diluting phase on the enantioselectivity of 2,6-Di-O-methyl-3-O-pentyl-β-cyclodextrin
✍ Bicchi, Carlo ;Artuffo, Giuseppe ;D'Amato, Angela ;Manzin, Valeria ;Galli, Anna 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 468 KB 👁 1 views

## Abstract As a continuation of previous studies on the use of cyclodextrin derivatives (CD) for the separation of volatile compounds by capillary GC, the influence of diluting phases other than OV‐1701 or OV‐1701‐OH has been investigated. 2,6‐Di‐__O__‐methyl‐3‐__O__‐pentyl‐β‐cyclodextrin (2,6‐Di