Synthesis and Silica-Based Immobilization of Monofunctionalized Heptakis(2,6-di-O-methyl-3-O-pentyl)-β-cyclodextrin for Enantioselective Capillary-HPLC

✍ Scribed by Dittmann, Helmutt ;König, Wilfried A.

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 133 KB
• Volume: 23
• Category: Article
• ISSN: 0935-6304
• DOI: 10.1002/1521-4168(20001001)23:10<583::aid-jhrc583>3.0.co;2-4

✦ Synopsis

Heptakis(2,6-di-O-methyl-3-O-pentyl)-b-cyclodextrin was monofunctionalized by the regioselective introduction of exactly one x-epoxyoctyl group at the primary site of the cyclodextrin. The site-specifically substituted cyclodextrin was immobilized to commercially available aminopropyl silica by nucleophilic opening of the epoxy function of the spacer substituent resulting in a lipophilic chiral stationary phase with broad applicability for enantiomer separations in capillary-