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Enantiodivergent Syntheses of γ-Substituted Butenolides with Tertiary and Quaternary Asymmetric Centers.

✍ Scribed by Katsufumi Suzuki; Kohei Inomata


Book ID
101941556
Publisher
John Wiley and Sons
Year
2003
Weight
279 KB
Volume
34
Category
Article
ISSN
0931-7597

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Enantiodivergent syntheses of γ-substitu
✍ Katsufumi Suzuki; Kohei Inomata 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 167 KB

Continuous nucleophilic addition with several organometallic reagents to tricyclic lactone (-)-1 proceeded diastereoselectively. Newly generated tertiary and quaternary asymmetric centers were controlled by the order in which the nucleophilic reagents were added. Using this methodology, enantiodiver