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Catalytic, Asymmetric Synthesis of Phosphonic γ-(Hydroxyalkyl)butenolides with Contiguous Quaternary and Tertiary Stereogenic Centers

✍ Scribed by Frings, Marcus; Thomé, Isabelle; Schiffers, Ingo; Pan, Fangfang; Bolm, Carsten


Book ID
121814378
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
403 KB
Volume
20
Category
Article
ISSN
0947-6539

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Continuous nucleophilic addition with several organometallic reagents to tricyclic lactone (-)-1 proceeded diastereoselectively. Newly generated tertiary and quaternary asymmetric centers were controlled by the order in which the nucleophilic reagents were added. Using this methodology, enantiodiver