Enantiodivergent Chemoenzymatic Synthesis of 4-Hydroxypiperidine Alkaloids
β Scribed by Laura Bartali; Andrea Casini; Antonio Guarna; Ernesto G. Occhiato; Dina Scarpi
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 258 KB
- Volume
- 2010
- Category
- Article
- ISSN
- 1434-193X
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π SIMILAR VOLUMES
The structure and absolute configuration of (-)-3-hydroxynorallosedamine 1, (-)-3-hydroxyallosedamine 2 and (-)-5-hydroxysedam%e 2, three new minor alkaloids isolated from Sedum acre, are reported. A nitrone-based synthesis of the new bases is described.
Both enantiomers of dideoxyfluoroamino inositols (+)-9 and (-)-9 were synthesized from bromocyclohexadiene cLv-diol I obtained by microbial oxidation of bromobenzene with toluene dioxygenase. Selective introduction of the amino group was achieved through S~2 displacement of trifates 7, l l. Fluorine