Enamines in Heterocyclic Synthesis: A Route to 4-Substituted Pyrazoles and Condensed Pyrazoles.
โ Scribed by Huwaida M. E. Hassaneen; Hamdi M. Hassaneen; Mohamed H. Elnagdi
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 25 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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โฆ Synopsis
Abstract
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๐ SIMILAR VOLUMES
## Abstract ฮฑโOxy/thio substituted ฮฒโketo esters were synthesized through an efficient crossโClaisen condensation of oxy/thio substituted acetic acid ethyl esters with acid chlorides, which in turn converted __in situ__ into 4โoxy/thio substitutedโ1__H__โpyrazolโ5(4__H__)โones by the addition of hy
## Abstract Dihydropyridazinones **4a**, **4b**, __N__โsubstituted dihydropyrazoles **5b**, **5c**, **5d**, and __O__โsubstituted pyrazoles **6a**, **6b**, **6c**, **6d** have been synthesized starting from spirocyclopropanepyrazole derivative **2**. Treatment of **2** with ฮฑโchloro esters, e.g., m