✦ LIBER ✦

Employing target modifications for the investigation of liquid infrared matrix-assisted laser desorption/ionization mass spectrometry

✍ Scribed by R. Cramer; A. L. Burlingame

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 235 KB
Volume: 14
Category: Article
ISSN: 0951-4198
DOI: 10.1002/(sici)1097-0231(20000130)14:2<53::aid-rcm833>3.0.co;2-h

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✦ Synopsis

We present a new target modification for commercial ion sources to facilitate the use of liquid matrices such as glycerol and lactic acid in infrared matrix-assisted laser desorption/ionization (IR-MALDI). Benefits of this modification include increased sensitivity compared with the unmodified commercial target, mass resolution comparable to the best achievable with conventional IR-MALDI or UV-MALDI, and decreased sample volatility leading to an analysis time extended up to fivefold compared with using conventional target designs (up to 1 hour using volumes of only 250 nL).

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