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EMMPRIN-mediated MMP regulation in tumor and endothelial cells

✍ Scribed by Stéphanie Caudroy; Myriam Polette; Béatrice Nawrocki-Raby; Jian Cao; Bryan P. Toole; Stanley Zucker; Philippe Birembaut

Book ID
110407588
Publisher
Springer
Year
2002
Tongue
English
Weight
166 KB
Volume
19
Category
Article
ISSN
0262-0898

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## Abstract Emmprin is a transmembrane glycoprotein on tumor cells that stimulates peritumoral fibroblasts to produce matrix metalloproteinases (MMPs). Emmprin and the induced MMPs play a crucial role in tumor progression, invasion and metastasis of human carcinomas (epithelial malignancies). Howev