Emergence of chronic myelogenous leukemia in a patient with primary thrombocythemia and absence of BCR/ABL rearrangement
โ Scribed by Jesus M. Cesar; Pablo Cabello; Teresa Ferro; J.L. Navarro
- Book ID
- 113512846
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 169 KB
- Volume
- 167
- Category
- Article
- ISSN
- 0165-4608
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๐ SIMILAR VOLUMES
## Abstract ## BACKGROUND Up to 5% of patients with chronic myelogenous leukemia (CML) do not have the Philadelphia (Ph) translocation t(9;22)(q34;q11) or a __bcr__/__abl__ molecular rearrangement. Although the diagnostic criteria of this entity are still under debate, there is general agreement t
The expression of c-abl, c-sis, c-myc and N-ras oncogenes was examined in 2 lymphoblastoid cell lines, one with Ph1 (PB-1049) and the other without Ph1 (LN-1049), both established from a patient with chronic myelogenous leukemia (CML), and in a Ph1-positive cell line (PB-1049-T) derived from a tumor
Cytogenetic and molecular studies were performed on 20 interferon-โฃ receiving Turkish chronic myelocytic leukemia patients. Four different restriction endonucleases and bcr-G probe were used for southern blot analysis to detect rearrangements of the bcr gene. The RT-PCR method was also applied to de