Embryo-fetal erythroid megaloblasts in the human coelomic cavity

✍ Scribed by Maria Concetta Renda; Antonino Giambona; Emanuela Fecarotta; Filippo Leto; George Makrydimas; Disma Renda; Gianfranca Damiani; Maria Cristina Jakil; Francesco Picciotto; Angela Piazza; Mauro Valtieri; Aurelio Maggio

• Book ID: 102314626
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 221 KB
• Volume: 225
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.22269

✦ Synopsis

Abstract

The coelomic cavity is part of the extraembryonic mesoderm, surrounding amniotic cavity, embryo, and yolk sac in the early gestation. It is now believed to represent an important transfer interface and a reservoir of nutrients for the embryo. Coelocentesis by ultrasound‐guided transvaginal puncture offers an easier access to the early human embryo, from 28 days post‐fertilization. However, despite some studies about its biochemical composition being reported, our knowledge about the presence of cellular elements and their quality in this compartment are still limited. Here we studied human coelomic fluids sampled from 6.6 (48 days) to 10 weeks of gestation, demonstrating the presence of functional embryonic erythroid precursors, that is, megaloblasts in the coelomic cavity. The ease of access of the coelomic cavity could allow the development of novel strategies for diagnostic or therapeutic purposes by ultrasound imaging and ultrasound‐guided puncture. J. Cell. Physiol. 225: 385–389, 2010. © 2010 Wiley‐Liss, Inc.